杨新旺

姓名:杨新旺

出生年月:1985年01月

基本情况:昆明医科大学,基础医学院,副教授,博士研究生,博导

行政职务:基础医学院党委委员、副院长

社会职务:

中国抗癌协会皮肤保护专业委员会副主任委员、中国毒理学会生物毒素毒理专业委员会委员、中国医药生物技术协会再生医学分会委员、全国大学生生命科学竞赛云南赛区委员会委员、中国医药生物技术协会科研实验室建设与管理分会委员、全国科技成果评价专家库(药学)专家、云南省人民政府发展研究中心专家库专家、一区TOP期刊Zoological Research编委和Burns & Trauma青年编委,北大核心《中华烧伤与创面修复》通讯编委。

招生专业:人体解剖学与组织胚胎学

研究领域:人体皮肤、黏膜屏障损伤修复再生与活性肽

培养研究生情况:

截止至2024年3月,培养指导4名博士研究生毕业1名、硕士研究生毕业20名;目前实验室在读博士研究生3名、硕士研究生27名。

电子邮件:yangxinwanghp@163.com、yangxinwang@kmmu.edu.cn

个人简介:

杨新旺博士立足于中国西南特有的生物资源优势,围绕云南省生物医药大健康产业发展重点方向,目前的研究兴趣主要围绕“重大人类疾病新型肽类分子干预策略及新机制解析、新药物靶标发现”;作为昆明医科大学“肽类分子探针与候选药物创新团队”带头人,依托依托教育部高原光损伤性皮肤病防治省部共建协同创新中心、教育部高原光损伤性皮肤病发病机制及综合防治研究创新团队,聚焦人体物理屏障(皮肤和粘膜)损伤修复再生与活性肽的研究工作;入选第一批“云南省高层次人才培养支持计划-万人计划青年拔尖人才”、“昆明市中青年学术技术带头人”、昆明医科大学“乘风人才”;获昆明医科大学“优秀共产党员”、“青年岗位能手”、“优秀教师”称号。

研究工作受国家自然科学基金、云南省基础研究杰出青年项目、重点项目和面上项目等支持;研究成果以通讯/第一作者身份发表/接收SCI研究论文70篇,代表性研究工作发表于国际著名期刊如PNAS、Pharmacological Research、Journal of Neuroinflammation、NPG Asia Materials、Cellular and Molecular Biology Letters、ACS Applied Materials & Interfaces、Journal of Nanobiotechnology、Journal of Biological Chemistry、the FASEB Journal、Journal of Proteome Research、Burns & Trauma等;获得国家发明专利授权23项,其中13项实现技术转移;指导研究生获得云南省优秀博士毕业论文1篇、云南省优秀硕士毕业论文3篇;指导本科生获得国家级学科竞赛奖励6项,国家级/省级/校级大创项目40项。


受教育经历:

2011.09-2014.07:中国科学院大学动物学专业博士研究生学习,获理学博士学位;

2007.09-2010.07:中国科学院研究生院动物学专业硕士研究生学习,获理学硕士学位;

2007.07-2007.09:研究生待入学;

2003.09-2007.07:云南大学生物科学专业本科学习,获理学学士学位。


工作经历:

2021.12-今:昆明医科大学基础医学院党委委员、副院长。

2021.03-2022.03:昆明医科大学基础医学院党委委员、人体解剖学与组织胚胎学系主任;

2020.01-2021.03昆明医科大学基础医学院人体解剖学与组织胚胎学系副主任(主持工作),期间:2020.12-今:昆明医科大学基础医学院党委委员;

2019.02-2020.01:昆明医科大学基础医学院人体解剖学与组织胚胎学系副主任(期间:2019.10取得副教授任职资格);

2015.09-2019.02:昆明医科大学基础医学院人体解剖学与组织胚胎学系教师(期间:2015.09取得讲师任职资格);

2014.07-2015.09:中国科学院昆明动物研究所,助理研究员。


主持或参加科研项目及人才计划项目情况(按时间倒序排序):

1. 国家自然科学基金地区科学基金项目, 32360138,蝌蚪来源的促皮肤创面组织再生肽类分子群的识别、功能及机制研究, 2024-01-01至2027-12-31, 33万元,在研,主持。

2.昆明医科大学中青年学科带头人及后备人选——“乘风”人才, 2023-07至2026-07, 50万元,在研,主持。

3.云南省基础研究计划重点项目, 202301AS070036,云南产臭蛙来源的促皮肤创面组织再生活性肽资源库的建立, 2023-06至2026-05, 50万元,在研,主持。

4.云南省基础研究计划杰出青年培育项目, 202301AY070001-301,短肽促皮肤创面组织再生的活性及作用机制研究, 2023-06至2026-05, 40万元,在研,主持。

5.云南省基础研究计划重点项目, 202101AY070001-006,活性肽HsTx1通过miR-1969/Lcn2/JAK2/STAT3途径抑制炎症抗癫痫发作的机制研究, 2021-09至2024-10, 40万元,在研,主持。

6. 国家自然科学基金地区基金,81760648,新型促皮肤创面愈合活性多肽的发现、结构、功能与机制研究,2018-01-01至2021-12-31,36万元,已结题,主持。

7. 云南省高层次人才培养支持计划—万人计划青年拔尖人才,2019-01至2023-12,100万元,在研,主持。

8. 昆明医科大学科技创新团队,CXTD202001,“肽类分子探针与候选药物”科技创新团队,2020-09至2023-08,30万元,在研,主持。


代表性论著

1、期刊论文

(1) Zhang YX#, Kang ZJ#, Wang JJ#, Liu SH, Liu X, Li ZR, Li YL, Wang YL, Fu Z, Li JY, Huang YB, Ru ZQ, Peng Y, Yang ZY, Wang Y*, Yang XW*, Luo MY*. Peptide OM-LV20 promotes arteriogenesis induced by femoral artery ligature via the miR-29b-3p/VEGFA axis.Atherosclerosis. 2024, https://doi.org/10.1016/j.atherosclerosis.2024.117487. (中科院大类2区TOP,IF=5.3,通讯作者)

(2) Jia QY#, Fu Z#, Li YS#, Kang ZJ, Wu YT, Ru ZQ, Peng Y, Huang YB, Luo YL, Li YH, Hu YR, Sun XH, Wang JY, Deng ZW*, Wu CY*, Wang Y*,Yang XW*. Hydrogel loaded with peptide-containing nanocomplexes: Symphonic cooperation of photothermal antimicrobial nanoparticles and pro-healing peptide for the treatment of infected wounds.ACS Applied Materials & Interfaces. 2024 Mar 5. doi: 10.1021/acsami.3c16061. Online ahead of print. (中科院大类1区TOP,IF=9.5,通讯作者)

(3) Li C#, Xiong Y#, Fu Z, Ji Y#, Yan J, Kong Y, Peng Y, Ru Z, Huang Y, Li Y, Yang Y, He L*, Tang J*, Wang Y*,Yang X*. The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds.Cellular & Molecular Biology Letters. 2024 Feb 5;29(1):24.(中科院大类1区TOP,IF=8.3,通讯作者)

(4) Sun D#, Guo K#, Liu N, Li Y, Li Y, Hu Y, Li S, Fu Z, Wang Y, Wu Y, Zhang Y, Li J, Li C, Wang Z, Kang Z, Sun J*, Wang Y*, Yang X*.Burns & Trauma. 2023 Nov 15;11:tkad035.(中科院大类1区TOP,IF=5.3,通讯作者)

(5) Li C#, Fu Z#, Jin T#, Liu Y, Liu N, Yin S, Wang Z, Huang Y, Wang Y, Zhang Y, Li J, Wu Y, He L*, Tang J*, Wang Y*,Yang X*. A frog peptide provides new strategies for the intervention against skin wound healing. Cellular & Molecular Biology Letters. 2023 Jul 28;28(1):61.(中科院大类1区TOP,IF=8.712,通讯作者)

(6) Yin S#, Wang Y*,Yang X*. Amphibian-derived wound healing peptides: chemical molecular treasure trove for skin wound treatment.Frontiers in Pharmacology. 2023 Jun 12;14:1120228.(中科院大类2区TOP,IF=5.988,通讯作者)

(7) Li Y#, Jin T#, Liu N#, Wang J#, Qin Z, Yin S, Zhang Y, Fu Z, Wu Y, Wang Y, Liu Y, Yang M, Pang A*, Sun J*, Wang Y*,Yang X*. A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis.Journal of Neuroinflammation. 2023 Feb 28;20(1):53. (中科院大类1区TOP,IF=9.589,通讯作者)

(8) Wu Y#, Wang Y#, Fu Z#, Sun H#, Liu Y, Li C, Wang Y, Liu N, Huang Y, Yin S, Guo K, Feng C, Tang J, He L, Yang Y*,Yang X*. Peptide RL-QN15 promotes regeneration of epidermal nerve fibers and recovery of sensory function in diabetic skin wounds. theFASEB Journal. 2023 Apr;37(4):e22892. (中科院大类2区TOP,IF=5.834,通讯作者)

(9) Liu N#, Fan Y#, Li Y#, Zhang Y, Li J, Wang Y, Wang Z, Liu Y, Li Y, Kang Z, Peng Y, Ru Z, Yang M, Feng C, Wang Y*, Yang X*. OL-FS13 alleviates cerebral ischemia-reperfusion injury by inhibiting miR-21-3p expression.Current Neuropharmacology. 2023;21(12):2550-2562.(中科院大类2区TOP,IF=7.708,通讯作者)

(10) Hu Y#, Meng B#, Yin S#, Yang M#, Li Y, Liu N, Li S, Liu Y, Sun D, Wang S, Wang Y, Fu Z, Wu Y, Pang A*, Sun J*, Wang Y*, Yang X*. Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis.Journal of Neuroinflammation. 2022 Dec 1;19(1):284. (中科院大类1区TOP,IF=9.589,通讯作者)

(11) Fu Z#, Sun H#, Wu Y#, Li C#, Wang Y, Liu Y, Li Y, Nie J, Sun D, Zhang Y, Liu N, Guo K, Yin S, Jia Q, Yang Y*, He L*, Wang Y*,Yang X*. A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients.NPG Asia Materials. 2022, 99:14 (中科院大类1区TOP,IF=10.761,通讯作者)

(12) Fu T#, Sun Y#, Gao W#, Long C, Yang C,Yang X, Zhang Y, Lan X, Huang S, Jin J, Murphy R, Zhang Y*, Lai* R, Hillis D*, Zhang Y*, Che J*. The highest-elevation frog provides insights into mechanisms and evolution of defenses against high ultraviolet radiation.Proceedings of the National Academy of Sciences of the United States of America. 2022 Nov 15;119(46):e2212406119. (中科院大类1区TOP,IF=12.779,参与作者)

(13) Sun H#, Yang Y#, Wu Y#, Fu Z#, Zhang Y, Liu Y, Nie J, Wang Y, Wang H, Mai B, Fu N, Li C, Liu N, Li Y, Deng Z*, He Li*, Wang Y*,Yang X*. Zinc alginate hydrogels with embedded RL-QN15 peptide-loaded hollow polydopamine nanoparticles for diabetic wound healing therapy.Materials & Design. 222 (2022) 111085.(中科院大类1区TOP,IF=9.417,通讯作者)

(14) Yin S#, Pang A#, Liu C#, Li Y, Liu N, Li S, Li C, Sun H, Fu Z, Wang Y, Zhang Y, Yang M*, Sun J*, Wang Y*,Yang X*. Peptide OM-LV20 exerts protective effects on astrocytes via the ‘PAC1R/JNK/TPH1’ axis to resist oxidative stress.Journal of Biological Chemistry. 2022 Aug 26; 298(10): 102429.(中科院大类2区TOP,Nature-index, IF=5.486,通讯作者)

(15) Qin P#, Tang J#, Sun D#, Yang Y#, Liu N, Li Y, Fu Z, Wang Y, Li C, Li X, Zhang Y, Liu Y, Wang S, Sun J, Deng Z*, He L*, Wang Y*,Yang X*, Zn2+ Cross-linked Alginate Carrying Hollow Silica Nanoparticles Loaded with RL-QN15 Peptide Provide Promising                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Treatment for Chronic Skin Wounds.ACS Applied Materials & Interfaces. 2022 Jul 6;14(26):29491-29505.(中科院大类1区TOP,IF=10.383,通讯作者)

(16) Zhang Y#, Yang Y#, Zeng L#, Liu Y, Sun H, Wang S, Shu L, Liu N, Yin S, Wang J, Ni D, Wu Y, Wang Y*, He L*, Meng B*,Yang X*, Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through miR-663a/TGF-?1/Smad axis.Burns & Trauma. 2022 Jul 12;10:tkac032.(中科院大类1区TOP,IF=5.711,通讯作者)

(17) Shu L#, Yang M#, Liu N#, Liu Y, Sun H, Wang S, Zhang Y, Li Y,Yang X*, Wang Y*. Short Hexapeptide Optimized from Rice-Derived Peptide 1 Shows Promising Anti-hyperuricemia Activities.Journal of Agricultural and Food Chemistry.2022 Jun 8;70(22):6679-6687. (中科院大类1区TOP,IF=5.895,通讯作者)

(18) Chun Xie#, Yan Fan#, Saige Yin#, Yilin Li, Naixin Liu, Yixiang Liu, Longjun Shu, Zhe Fu, Yinglei Wang, Yue Zhang, Xiaojie Li, Ying Wang*, Jun Sun*,Xinwang Yang*. Novel amphibian-derived antioxidant peptide protects skin against ultraviolet irradiation damage. Journal of Photochemistry & Photobiology, B: Biology. 2021 Sep 30; 224:112327. doi: 10.1016/j.jphotobiol.2021.112327. (中科院小类1区TOP,IF=6.252,通讯作者)

(19) Huiling Sun#, Ying Wang#, Tiantian He#, Dingwei He#, Yan Hu, Zhe Fu, Yinglei Wang, Dandan Sun, Junsong Wang, Yixiang Liu, Longjun Shu, Li He*, Ziwei Deng*,Xinwang Yang*. Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds. Journal of Nanobiotechnology. 19, 304 (2021).(中科院大类1区TOP,IF=10.435,通讯作者)

(20) Pan Qin#, Yi Meng#, Ying Yang#, Xinyu Gou, Naixin Liu, Saige Yin, Yan Hu, Huiling Sun, Zhe Fu, Yinglei Wang, Xiaojie Li, Jing Tang, Ying Wang*, Ziwei Deng*,Xinwang Yang*. Mesoporous polydopamine nanoparticles carrying peptide RL-QN15 show potential for skin wound therapy.Journal of Nanobiotechnology. 2021 Oct 9;19(1):309.(中科院大类1区TOP,IF=10.435,通讯作者)

(21) Wang Y#, Feng Z#, Yang M#, Zeng L#, Qi B, Yin S, Li B, Li Y, Fu Z, Shu L, Fu C, Qin P, Meng Y, Li X, Yang Y, Tang J*,Yang X*. Discovery of a novel short peptide with efficacy in accelerating the healing of skin wounds. Pharmacological Research. 2021 Jan; 163:105296.(中科院大类1区TOP,IF=10.331,通讯作者)

(22) Liu N#, Meng B#, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Yang M, Wang Y*,Yang X*. Discovery of a novel rice-derived peptide with significant anti-gout potency.Food Function. 2020 Dec 1;11(12):10542-10553.(中科院大类1区TOP,IF=5.396,通讯作者)

(23) Liu N#, Wang Y#, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Li Y, Sun H, Yang M, Sun J*,Yang X*. RDP3, A Novel Anti-Gout Peptide Derived from Water Extract of Rice.Journal of Agricultural and Food Chemistry. 2020 Jul 8;68(27):7143-7151.(中科院大类1区TOP,IF=5.279,通讯作者)

(24) Liu N#, Wang Y#, Yang M#, Bian W, Zeng L, Yin S, Xiong Z, Hu Y, Wang S, Meng B*, Sun J*,Yang X*. New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats.Journal of Agricultural and Food Chemistry. 2019 Jan 9;67(1):220-228.(中科院大类1区TOP,IF=5.279,通讯作者)

(25)Cao X#, Wang Y#, Wu C#, Li X, Fu Z, Yang M, Bian W, Wang S, Song Y, Tang J*,Yang X*. Cathelicidin-OA1, a novel antioxidant peptide identified from an amphibian, accelerates skin wound healing.Scientific Reports. 2018 Jan 17;8(1):943.(通讯作者,三区,IF=4.122)

(26)Yang X#, Wang Y#, Zhang Y, Lee WH, Zhang Y*. Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians.Scientific Reports, 2016 Jan 27;6:19866. (第一作者,IF=5.228)

(27)Yang X#, Lee WH*, Zhang Y*. Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.Journal of Proteome Research, 2012 Jan 1;11(1):306-19. (第一作者,IF=5.754,封面文章)


2、专利

(1)杨新旺;王滢;唐璟;曹小青;李小洁;边温馨;宋咏丽;王思媛;刘乃心。一种皮肤创伤修复肽WHPP?OA1及其提纯方法与应用。2017-11-7,专利号:ZL201711087232.5。完成技术转移。

(2)杨新旺;孙俊;宋咏丽;唐璟;吴春云。一种多肽OA-GL12及其应用。2018-10-26,专利号:ZL201811258084.3。完成技术转移。

(3)杨新旺;孙俊;孟步亮;刘乃心;王滢。一种多肽RDP1及其提纯方法与应用。2018-11-30,专利号:ZL201811456981.5。 完成技术转移。

(4)孟步亮; 杨新旺;王滢;边温馨;庞爱兰。一种多肽OA-GL21及其提纯方法与应用。2018-4-23,专利号:ZL201810366406.X。完成技术转移。

(5)孟步亮;杨新旺; 王滢;刘乃心;李哲;庞爱兰。一种多肽OA-FF10及其提纯方法与应用。2018-4-23,专利号:ZL201810366376.2。完成技术转移。

(6)陶剑;余姗;杨新旺; 尹赛格;杨兆宇。一种抗皮肤光损伤保护活性多肽RL-PL9及其应用。2020-11-16,专利号:ZL202011275951.1。

(7)杨新旺; 王滢;孙俊;刘乃心;唐璟。一种抗痛风活性多肽RDP3及其制备方法与应用。2020-5-21,专利号:ZL202010436599.9。

(8)杨新旺; 王滢;唐璟;孙俊;刘乃心。一种抗痛风活性多肽RDP2及其制备方法与应用,2020-5-21,专利号:ZL202010436608.4。

(9)杨新旺;王滢;王思媛;唐璟;李自良。一种皮肤修复多肽RL-RL10及其应用。2019-8-29,专利号:ZL201910805493.9。完成技术转移。

(10)杨新旺;王滢;唐璟;冯卓;杨莹;尹赛格;刘乃心;孙慧玲;李依林;傅阳。一种皮肤保护肽HW-P1及其制备方法与应用。2019-9-25,专利号:ZL201910913216.X。

(11)杨新旺;王滢;唐璟;王思媛;李自良。一种皮肤创伤修复肽RL-RF10及其提纯方法与应用。2019-9-2,专利号:ZL201910821005.3。完成技术转移。

(12)杨新旺;罗明英;冯成安;张心平;杨美凤。一种抗光损伤皮肤保护活性多肽OM-GL15及其应用。2020-6-2,专利号:ZL202010487427.4。完成技术转移。

(13)杨新旺; 杨莹;唐璟;王滢;刘乃心;孟步亮;杨美凤;李依林;孙慧玲。一种促皮肤创伤修复的抗氧化多肽OA-GL17及其制备方法与应用。2019-10-12,专利号:ZL201910966274.9。完成技术转移。

(14)杨新旺;王滢;杨莹;刘乃心;唐璟;杨美凤;傅阳;孙慧玲;李依林。一种促皮肤愈合肽OA-GP11及其制备方法与应用。2019-10-12,专利号:ZL201910966166.1。完成技术转移。

(15)杨新旺; 孙俊;杨美凤;唐璟;谢纯;李依林;尹赛格。一种活性多肽OS-LL11及其应用。2020-5-25,专利号:ZL202010448713.X。完成技术转移。

(16)杨莹;杨新旺;李奕平;赵建;唐璟;陶剑。一种皮肤保护肽OM-TV16及其制备方法与应用。2019-10-12,专利号:ZL 201910968764.2。完成技术转移

(17)杨新旺;孙俊;杨美凤;王滢;宋咏丽;尹赛格。一种具有改善脑缺血缺氧的蝎子毒素活性多肽HsTx1及其制备方法与应用。2019-9-3,专利号:ZL 201910828424.X。

(18)陶剑;余姗;杨新旺; 尹赛格;杨兆宇。一种抗氧化损伤皮肤保护活性多肽RL-PP10及其应用。2020-11-16,专利号:ZL 202011275745.0。

(19)王滢;杨新旺;王颖蕾;付喆;贾秋叶;李依林;刘以香;魏子淇。miR-632在制备治疗皮肤创伤修复药物中的应用。2024-02-20,专利号:ZL202211207361.4。

(20)杨新旺;王滢;李依林;尹赛格;王颖蕾;杨美凤;刘承杏;冯成安;刘乃心;吴雨桐。一种泽蛙来源促神经损伤修复活性多肽HW-P3及其应用。2023-06-20,专利号:ZL202210587137.6。

联系方式

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